An Epic Leap For Mental Health

Gilgamesh is a clinical-stage biotech whose vision is to reshape how mental illnesses are treated by shifting away from symptom management to a focus on rapid-acting and durable therapies targeting the fundamental drivers of disease. We do this by designing best-in-class new chemical entities (NCEs) acting through proven mechanisms, which are optimized for safety, efficacy, and patient access

Our programs

Deep expertise in medicinal chemistry combined with our AI-powered discovery and translational platform accelerates the creation of our novel precision psychiatric therapies.

NMDAR Antagonist 
  • Orally bioavailable

  • Rapid-acting

  • Fewer dissociative effects

  • Depression and other indications

  • New Chemical Entity

5-HT2AR Agonists
  • Rapid acting anti-depressants

  • Optimized duration of effect

  • Improved cardiac safety profile

  • Depression and other indications

  • New Chemical Entities

Safer Ibogaine Analogs
  • Rapid and sustained efficacy

  • Improved cardiac safety profile

  • Opioid abuse disorder and other indications

  • New Chemical Entity

Our Pipeline
Our Partners

We collaborate with research institutions at the forefront of biotech innovation.

Columbia University LogoNIDA LogoNYU Logo
our team
Learn more about partnerships, investment, and career opportunities
Contact Us
Gilgamesh Pharmaceuticals
113 University Place, Suite 1019, NY, NY 10003